Saint Charles, resting on 500 acres in Carthagena, Ohio, is the central house for the Cincinnati Province of the Missionaries of the Precious Blood. This apostolic community of priests and brothers was founded on August 15, 1815, by St. Gaspar del Bufalo, in Rome, Italy, and began missionary service in the United States in 1844.

Several hundred acres were purchased in 1861 by the Missionaries of the Precious Blood to provide for a seminary for Precious Blood priests and brothers. The main building was completed in 1922. The beautiful Romanesque chapel, built in 1906 and subsequently remodeled, is attached to the center rear of the building. The seminary closed in 1969 and the building was named St. Charles Center, primarily a home for active and retired priests and brothers.

In 2006, the main building was renovated into independent apartments for people age 55 and above, religious and laity, and is now known as the Saint Charles Senior Living Community.

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